2-Server PIR with sub-polynomial communication

A 2-server Private Information Retrieval (PIR) scheme allows a user to retrieve the $i$th bit of an $n$-bit database replicated among two servers (which do not communicate) while not revealing any information about $i$ to either server. In this work we construct a 1-round 2-server PIR with total communication cost $n^{O({\sqrt{\log\log n/\log n}})}$. This improves over the currently known 2-server protocols which require $O(n^{1/3})$ communication and matches the communication cost of known 3-server PIR schemes. Our improvement comes from reducing the number of servers in existing protocols, based on Matching Vector Codes, from 3 or 4 servers to 2. This is achieved by viewing these protocols in an algebraic way (using polynomial interpolation) and extending them using partial derivatives

Mood Disorders and Trauma – What are the Associations?

Objectives: To characterize the relationship between childhood trauma/abuse, and mood dysregulation, and between childhood trauma/abuse and pediatric bipolar disorder (BD). To describe the clinical correlates and demographics of children with trauma/abuse and comorbid mood disorders in a community mental health setting. To explore associations between the diagnosis of BD in youth with histories of trauma and a family history of BD, the presence of specific symptom clusters, the presence of pretrauma mood symptoms. Methods We are assessing youths ages 8-18 who present with mood symptoms and past trauma divided into two groups: (1) Trauma Mood Disorder NOS (T+MD); (2) Trauma+Unmodified DSM-IV-TR BD (T+BD). Differences in clinical variables between groups are analyzed using t-tests for continuous and chi-square tests for categorical variables (α= 0.05). Youth are evaluated using the following psychiatric rating scales: (1) Structured Clinical Interview for DSM Disorders, Childhood Disorders Form (KID-SCID) mood module to establish the diagnosis of BD; (2) Brief Psychiatric Rating Scale for Children (BPRS-C); (3)Young Mania Rating Scale (YMRS); (4)Children’s Depression Rating Scale-Revised (CDRS-R); (5) Childhood Trauma Questionnaire (CTQ); (6) PTSD CheckList –Civilian Version (PCL-C); (7)Attention Deficit Hyperactivity Disorder IV (ADHD-IV) Rating Scale; (8) Substance Abuse (SA) screen: CRAFFT Other information obtained includes: Demographic characteristics and socioeconomic status; Number of medications and types; Percent of with a lifelong history of psychiatric hospitalization/out of home placement; Family history of psychiatric illness and substance use disorders Results - Clinical presentations: Mood Symptoms: BD\u3eMD in BPRS total score (p=0.06), BPRS Mania subscale (p=0.05),YMRS total score (p=0.06) BD\u3eMD in total number of mood episodes identified with KID-SCID: •MDE (p=0.04) Mania (without high outlying value) (p = 0.07) Substance use: No difference as assessed using CRAFT PTSD and trauma recollection: No differences in PTSD symptoms as assessed by PCL-C BD\u3eMD abuse identified with CTQ. Sexual abuse (without high outlying value) (p = 0.05). Physical neglect (p=0.07) Medications: BD\u3eMD 1.33 fewer medications (t=11.9, p=0.17) Conclusions Further data collection is ongoing to achieve our targeted sample size in order to identify clinical correlates in mood dsyregulated, traumatized youth. This will promote future research aimed at identifying biomarkers and preventive interventions

Mood Disorders and Trauma – What are the Associations? Future Directions

Background: Mood dysregulation in traumatized children often is misdiagnosed as Bipolar Disorder (BD) and conversely the diagnosis of BD is often overlooked. This presents a diagnostic quagmire that is critical to understand in more depth and to date has received little attention in the literature. We aim to characterize the relationship between childhood trauma and mood dysregulation and between childhood trauma and pediatric BD by describing clinical correlates of children with trauma and comorbid mood disorders in a community mental health setting. Methods: 40 youth between the ages of 8-18 years, who present to child psychiatry at Community Healthlink clinics with symptoms of mood dysregulation and history of trauma will be assessed. Children will be divided into two groups: (1) Mood Disorder NOS (MD NOS) (n=20); and (2) Unmodified DSM-IV-TR BD (n=20) At the end of 6 months, youth with MD NOS will be re-evaluated to determine if progressed to the diagnosis of BD Future Directions Better understanding the association between trauma and development of mood disorders will increase our knowledge of the diverse effects of such events on youths’ emotional and behavioral development Identifying clinical correlates that help predict later development of BD in mood dsyregulated, traumatized youth, will promote future research aimed at identifying biological markers and preventive treatment interventions Presented at the UMass Department of Psychiatry Research Day, October 2010

Crystal Ball: From Innovative Attacks to Attack Effectiveness Classifier

Android OS is one of the most popular operating systems worldwide, making it a desirable target for malware attacks. Some of the latest and most important defensive systems are based on machine learning (ML) and cybercriminals continuously search for ways to overcome the barriers posed by these systems. Thus, the focus of this work is on evasion attacks in the attempt to show the weaknesses of state of the art research and how more resilient systems can be built. Evasion attacks consist of manipulating either the actual malicious application (problem-based) or its extracted feature vector (feature-based), to avoid being detected by ML systems. This study presents a set of innovative problem-based evasion attacks against well-known Android malware detection systems, which decrease their detection rate by up to 97%. Moreover, an analysis of the effectiveness of these attacks against VirusTotal (VT) scanners was conducted, empirically showing their efficiency against well-known scanners (e.g., McAfee and Comodo) as well. The VT system proved to be a great candidate for the attacks, as in 98% of the apps, less scanners detected the manipulated apps than the original malicious apps. As not all the attacks are effective in the same manner against the VT scanners, the attack efficiency classifiers are advised. Each classifier predicts the applicability of one of the attacks. The set of classifiers creates an ensemble, which shows high success rates, allowing the attacker to decide which attack is best to use for each malicious app and defense system

Holevo's bound from a general quantum fluctuation theorem

We give a novel derivation of Holevo's bound using an important result from nonequilibrium statistical physics, the fluctuation theorem. To do so we develop a general formalism of quantum fluctuation theorems for two-time measurements, which explicitly accounts for the back action of quantum measurements as well as possibly non-unitary time evolution. For a specific choice of observables this fluctuation theorem yields a measurement-dependent correction to the Holevo bound, leading to a tighter inequality. We conclude by analyzing equality conditions for the improved bound.Comment: 5 page

Mood Disorders and Trauma: What are the Associations?

Objectives: Mood dysregulation in traumatized children may be misdiagnosed as bipolar disorder (BD) and conversely, the diagnosis of BD overlooked. Our aim is to characterize the relationship between trauma and mood dysregulation and pediatric BD. Methods: We are assessing youths ages 8-18 who present with mood symptoms and past trauma divided into two groups: 1. Trauma+Unmodified DSM-IV-TR BD (T+BD) and 2. Trauma+Mood Disorder NOS (T+MD). Differences in clinical variables between groups are analyzed using t-tests for continuous and chi-square tests for categorical variables (α= 0.05). Results: Age at onset of trauma for youth with T+BD (n=10) compared with T+MD (n=10) was similar (2.6±1.8 versus 3.3±1.9 years; p=0.4) as were types of trauma and number of incidents, and age at onset of mood symptoms (T+BD 7±2.5 versus T+MD 7.8±1.8 p=0.4). The T+BD group had higher scores on the sexual abuse subscale of the Childhood Trauma Questionnaire (p=0.04) and BPRS mania subscale (p=0.02), and higher total number of major depressive episodes (p=0.04) and manic episodes (p=0.03) per the KSCID. Youth with T+BD reported a trend toward higher rates of ideation to self-harm compared to youth with T+MD (p=0.08). Both groups had similar PTSD and ADHD symptoms, and similar number of psychotrophic medications (BD 3.6±2.9 MD 2.7±2.1 p=0.4). Finally, family history findings suggest a trend towards higher rates of any Axis I disorder in the T+BD families (p=0.07), and significantly higher rates of anxiety disorders (p=0.05), BD (p=0.04), and schizophrenia (p=0.02). Conclusions: Results suggest differences in clinical presentation and higher rates of BD and schizophrenia in the T+BD families. Taken together, these preliminary results suggest potential biological and genetic vulnerabilities which may predispose children to develop specific mood disorders under certain circumstances; the ability to identify these children early on could change their prognostic trajectory

Clobetasol 17-Propionate Cream as an Effective Preventive Treatment for Drug Induced Superficial Thrombophlebitis

Commonly used therapies for thrombophlebitis have a high failure rate. There are scant data on the application  of topical corticosteroids to treat thrombophlebitis. The present study investigated if the potent topical  corticosteroid clobetasol 17-propionate cream (Dermovate, Glaxo Wellcome) can be an effective treatment  for drug-induced thrombophlebitis. DP-b99, a neuroprotective agent currently undergoing development for acute stroke, can cause injectionsite  phlebitis. DP-b99 was administered at doses of 1 and 2 mg/kg by a 1 hour intravenous infusion into the  lateral ear vein of groups of 6 and 5 rabbits, respectively. Each rabbit served as its own control by injecting  both ears with DP-b99, while treating only one ear with clobetasol cream immediately after treatment, with  subsequent applications twice daily for 3 days. Phlebitis was evaluated 1, 3, 5, 24, 32, 48, 56 and 72 hours  after DP-b99 treatment using a clinical score ranging from 0 (no reaction) to 4. After 3 days the rabbits were  sacrificed for histological analysis of the ears. The phlebitis score was highest at 24 hours. Clobetasol treatment reduced the clinical scores at all time points and shortened the course of phlebitis. Maximal effect was observed 24-48 hours after the first application  of clobetasol cream. Histologically, there were fewer cases of thrombophlebitis in the clobetasoltreated  ears, and those seen were milder and more focal. To the best of the authors’ knowledge this appears  to be the only study to report a phlebitis-ameliorating effect of a topical corticosteroid.

Heterogeneity in HIV and cellular transcription profiles in cell line models of latent and productive infection: implications for HIV latency.

BackgroundHIV-infected cell lines are widely used to study latent HIV infection, which is considered the main barrier to HIV cure. We hypothesized that these cell lines differ from each other and from cells from HIV-infected individuals in the mechanisms underlying latency.ResultsTo quantify the degree to which HIV expression is inhibited by blocks at different stages of HIV transcription, we employed a recently-described panel of RT-ddPCR assays to measure levels of 7 HIV transcripts ("read-through," initiated, 5' elongated, mid-transcribed/unspliced [Pol], distal-transcribed [Nef], polyadenylated, and multiply-sliced [Tat-Rev]) in bulk populations of latently-infected (U1, ACH-2, J-Lat) and productively-infected (8E5, activated J-Lat) cell lines. To assess single-cell variation and investigate cellular genes associated with HIV transcriptional blocks, we developed a novel multiplex qPCR panel and quantified single cell levels of 7 HIV targets and 89 cellular transcripts in latently- and productively-infected cell lines. The bulk cell HIV transcription profile differed dramatically between cell lines and cells from ART-suppressed individuals. Compared to cells from ART-suppressed individuals, latent cell lines showed lower levels of HIV transcriptional initiation and higher levels of polyadenylation and splicing. ACH-2 and J-Lat cells showed different forms of transcriptional interference, while U1 cells showed a block to elongation. Single-cell studies revealed marked variation between/within cell lines in expression of HIV transcripts, T cell phenotypic markers, antiviral factors, and genes implicated in latency. Expression of multiply-spliced HIV Tat-Rev was associated with expression of cellular genes involved in activation, tissue retention, T cell transcription, and apoptosis/survival.ConclusionsHIV-infected cell lines differ from each other and from cells from ART-treated individuals in the mechanisms governing latent HIV infection. These differences in viral and cellular gene expression must be considered when gauging the suitability of a given cell line for future research on HIV. At the same time, some features were shared across cell lines, such as low expression of antiviral defense genes and a relationship between productive infection and genes involved in survival. These features may contribute to HIV latency or persistence in vivo, and deserve further study using novel single cell assays such as those described in this manuscript

Psychiatric Symptomatology, Mood Regulation, and Resting State Functional Connectivity of the Amygdala: Preliminary Findings in Youth With Mood Disorders and Childhood Trauma

Background: As mood dysregulation and hyperarousal are overlapping and prominent features of posttraumatic stress disorder (PTSD), and mood disorders (MD) including bipolar disorder (BD), we aimed to clarify the role of trauma and MD on the resting state functional connectivity (RSFC) of amygdala in MD youth with or without trauma exposure, and healthy controls (HC). Methods: Of 23 subjects, 21 completed the magnetic resonance imaging (MRI) protocol, 5 were excluded for subject motion, leaving final sample size of 16: nine subjects with MD (5/9 with trauma), and 7 HC. Youth were assessed with Schedule for Affective Disorders and Schizophrenia for School Aged Children-Present and Lifetime Version (K-SADS-PL), and other behavioral measures including Young Mania Rating Scale (YMRS). Imaging data were acquired using functional MRI in 3-T scanner. Imaging included T1-weighted structural MRI and 6-min resting state acquisition. Results: In between group analysis, the average correlation coefficients between left anterior cingulate cortex (Acc) and left insula cortex with left amygdala regions were significantly larger in HC compared to the patient population. Connectivity between left amygdala and left cingulate cortex shows a significant negative correlation with YMRS severity. Conclusions: In this preliminary study, MD with trauma youth had more manic symptoms and difficulties regulating anger. While MD youth showed reduced RSFC of left amygdala with left acc and left insula, no significant difference between the subgroups of children with MD was observed. However, when looking at both clinical groups together, we observed a significant correlation of RSFC of left amygdala to left acc, and YMRS scores